ORTHOPEDIC FORCE에 의한 백서악관절 주위조직의 변화에 대한 조직학적 연구
A HISTOLOGICAL STUDY ON THE CHANGES OF THE SURROUNDING TISSUE IN MANDIBULAR JOINT BY THE ORTHOPEDIC FORCE IN RATS
이백민,
소속 상세정보
이백민 ( ) - 연세대학교 대학원 치의학과
KMID : 0361919830130020155
Abstract
This experiment was performed to study the effect of PGEZ on the bone resorption at the tooth movement by orthodontic force. The experimental animals were the Sprague-Dawley strain rats.
The orthodontic force was applied by the insertion of separating clamp made of 0.014" (0.356mm) wire to the interproximal site between the 2nd and the 3rd upper right molars.
In experiment I, 0.2μg, 0.4μg, 0,8μg, and 1.0μg PGE2 were locally injected at the submuc 3sa near the 2nd molar of the maxilla each. The effect was detected by the count of the number of osteoclasts appeared at the compressed surface of interradicula . bone.
In experiment II, 1.0 mg/kg indomethacm (a specific inhibitor of prostaglandin synthetase) was subcutaneously injected. The effect was examined by the count of the number of cateoclasts appeared at the compressed surface of interradicular bone.
The obtained results were follows;
1. The number of osteoclasts on the compressed surface of the interradicular bone increased in proportion to the increased dosage of PGE2 administered.
The number of osteoclasts increased significantly at the administration of 0.8μg, and 1.0μg PGEZ in contrast to the control (P < 0.05).
2. ´ The administration of 1.0 mgJkgg indomethacin decreased the number of osteoclasts at the compressed bony surface significantly (P< 0.01).
키워드
원문 및 링크아웃 정보
등재저널 정보